After that restart windows and open iTunes, it’s working correctly. If problems are detected then the troubleshooter will try to resolve the issue. Apparently, there is a widespread problem: If you. This will diagnose your system and detects any problems that might be preventing any Windows Store apps from working correctly. Apple is currently distributing the update to iTunes 12/12/06 for Windows 10 via the Microsoft Store. Scroll down to the bottom and select Windows Store Apps.Click Update & security then Troubleshoot Lets check out how you can fix this iTunes error 21 issue.Press Windows Key+X and select Settings.If not Run the build-in store app troubleshooter and let windows check and fix the problem for you. When the window closes, the job is done, lets open iTunes to check working properly.A command prompt window should show up, which indicates that Windows is resetting the Store cache.Type command wsreset and press the enter key.Open the command prompt as administrator.And Clear the windows store cache is a useful solution to fix the issue. Sometimes, due to corrupted store cache, windows apps start misbehaving, like freezes, not responding at startup, include iTunes (windows store app) not working.